Complex N-Acetylation of Triethylenetetramine
نویسندگان
چکیده
منابع مشابه
Complex N-acetylation of triethylenetetramine.
Triethylenetetramine (TETA) is an efficient copper chelator that has versatile clinical potential. We have recently shown that spermidine/spermine-N(1)-acetyltransferase (SSAT1), the key polyamine catabolic enzyme, acetylates TETA in vitro. Here, we studied the metabolism of TETA in three different mouse lines: syngenic, SSAT1-overexpressing, and SSAT1-deficient (SSAT1-KO) mice. The mice were s...
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7. FUWA, K., WACKER, W. E. C., DRUYAN, R., BARTHOLOMY, A. F., AND VALLEE, B. L., Proc. Katl. Acad. Sci. U. S., 46, 1198 (1960). MAHLER, H. R., DUTTON, G., AND MEHROTRA, B. D., Biochim. et Btiphys. Acta, 68, 199 (1963). 8. 9. FRESCO, J. R., ALBERT, B. M., AND DOTY, P., Nature, 188, 98 (1960). BRUNNGRABER, E. F., Biochem. and Biophys. Research Communs., 8, 1 (1962). 10. VON EHRENSTEIN,G., AND LIP...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2011
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.111.041798